Recent studies have shown that MR spectroscopy, diffusion‐weighted imaging (DWI), diffusion tensor imaging (DTI), and arterial spin labeling (ASL) perfusion MR imaging are promising in predicting IDH1 mutation status in glioma.34, 40, 41, 42 Incorporating features calculated from these new modalities may potentially improve the performance of our multiregional model. The gene discussed is IDH1; the disease is central nervous system cancer.