Due to the multiregional and microenvironmental heterogeneity in GBM,19 the high prognostic and predictive value of multiregional radiomics model from multiparametric MRI has been widely recognized.20, 21, 22 It is a reasonable hypothesis that imaging features from multiple tumor subregions could have the best accuracy in predicting IDH1 mutation than those from single subregion. This evidence concerns the gene IDH1 and neoplasm.