Plg levels were not affected by hyperglycaemia that, on the contrary, reduced plasmin activity by 1.3‐fold (P < 0.01) and increased MMP‐2/MMP‐9 levels and activity by 2.2‐, 2.4‐ and 2.2‐fold (P < 0.001). Here, PLG is linked to Hyperglycemia.