DNM2 and autosomal dominant centronuclear myopathy: Lastly, in a model of DNM2-related CNM, Trochet et al. [79] successfully reduced mutant DNM2 protein and mRNA levels in murine and patient fibroblast models of ADCNM using allele-specific silencing RNA (siRNA) against the ADCNM-associated p.R465W mutation.