Only a study reported by Zhou et al. evaluated serum autoantibodies to a panel of seven tumor-associated antigens (C-myc, IMP1, Koc, p16, p53, p62 and Survivn) in the patients with EJA and indicated that autoantibodies might be useful to differentiate patients with EJA from normal controls [12]. This evidence concerns the gene TP53 and neoplasm.