Following dissociation of Grp78, PERK-eIF2α (phosphorylate eukaryotic initiation factor2α) axis is activated and suppresses polypeptide synthesis through translational attenuation to prevent further accumulation of misfolded proteins within the ER, and thus relieving the cancer cells from intracellular stress to favor cancer survival [19]. The gene discussed is EIF2A; the disease is cancer.