Our study also highlights several putative novel NRF2 target genes, including F2RL2, TRIM16L and the pseudogene LOC344887. Whilst further work is needed to define the biological significance of the interaction between NRF2 and these genes, LOC344887 (also known as NMRAL2P) was recently shown to respond to sulforaphane and regulate the NRF2-dependent induction of NQO1 in colon cancer cells (Johnson et al. 2017). Here, F2RL2 is linked to malignant colon neoplasm.