VEGFA and neoplasm: Most recently, in addition to VEGF assessment in serum and plasma, platelet-derived VEGF measurements have been accepted, supported by clinical evidences of platelets scavenging of tumor-derived VEGF [12, 13] and pre-clinical data indicating that VEGF levels within platelets change significantly in the presence of the tumor, even in a tumor mass smaller than 1 mm3, which cannot be detected with conventional and applicable clinically methods [14].