The inversed relation of TNF-α and IL-6 levels has also been described as a defense mechanism of the fungus: IL-6 can inhibit the production of TNF-α, which is directly related to macrophage function in PCM models and acts on granuloma formations and the modulation of fungicidal activity [4, 6, 35]. The gene discussed is IL6; the disease is paracoccidioidomycosis.