CAV1 and graft versus host disease: In CD4 T cells, caveolin-1 plays a structural role and is needed for the optimal clustering of Lck and the TCR; T cell grafts from wild type and Cav1−/− mice are equally potent at inducing graft vs. host disease (GVHD) when depleted of regulatory T cells (Tregs), indicating that Cav1−/− Tregs are equally protective (Schonle et al., 2016).