In addition, Gal-3 secretion by macrophages is a major driver of fibroblast activation and subsequent myofibroblast accumulation during the progression of several organs to fibrosis (Henderson et al., 2006, 2008; Jaquenod De Giusti et al., 2015), plays a critical and complex context-dependent role in the kidneys (Chen and Kuo, 2016) and have an enhanced expression in chronic murine leptospirosis (Ferrer et al., 2014). The gene discussed is LGALS3; the disease is leptospirosis.