G6PC1 and Sepsis: Moreover, a recent study demonstrated that the induction of ferritin heavy chain (FTH) in response to polymicrobial infections was critical to establishing disease tolerance to sepsis and that the protective effect of FTH was exerted via countering iron-dependent oxidative inhibition of the liver glucose-6-phosphatase (G6Pase) to sustain endogenous glucose production via liver gluconeogenesis [32].