SERPINE1 and metabolic syndrome: The report is based on evidence of increased various proinflammatory cytokines (e.g., interleukin 1β (IL-1β), IL-8, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor α (TNFα), and prothrombotic mediator plasminogen activator inhibitor-1 (PAI-1)), as well as biomarkers of inflammation (e.g. C-reactive protein (CRP)) concentration in MetS individuals [50, 51].