CD3+CD4+LAP+ cells (which express surface TGF-β linked to its latency associated peptide [LAP]) have been shown to limit inflammation in the adoptive transfer mouse model of experimental colitis (28) and are crucial to ensure protection against murine TNBS colitis, since transfer of CD4+LAP+ depleted cells with intact CD4+Foxp3+ cells does not prevent TNBS colitis in recipient mice (29). The gene discussed is CD4; the disease is colitis.