CD4 and colitis: This colitis was associated with significantly higher percentages of LP CD3+CD4+LAP+ cells (Figure 4C) in uninvolved tissue as compared with both involved tissue and with tissue from untreated control mice, and a higher percentage of CD3+CD4+Foxp3+ cells in involved tissue as compared with both uninvolved tissue and control untreated mice (Figure 4D), thus reproducing the observations made in UC patients.