HIF1A and neoplasm: Liu et al. showed that lineage differentiation of MDSCs to M1 cells requires glycolytic activity induced by mTOR- and HIF-1α, as brought about by SIRT1 in tumors (56), while Cocl2 (an HIF-1α activator) effectively promotes M1-MDSC differentiation, and potentiates tumor-killing and glycolytic activities.