Currently, everolimus, a rapamycin derivate, is being tested as HDT in patients with moderate to far advanced pulmonary tuberculosis (together with vitamin D, auranofin [a gold complex with antimicrobial activity used in rheumatoid arthiritis], and CC-11050 [a phosphodiesterase 4 (PDE4) inhibitor]), using rifabutin-based anti-TB treatment (ClinicalTrials.gov NCT02968927); with change in FEV1 being one of the secondary outcomes. The gene discussed is PDE4A; the disease is tuberculosis.