IL1B and tuberculosis: Increasing PGE2 by early (day one post infection) administration of exogenous PGE2 (dinoproston – normally used for induction of labor) and/or the 5-lipo-oxygenase inhibitor zileuton (used in the treatment of asthma) to IL-1 deficient mice resulted in less necrotic lung pathology by TB (Mayer-Barber et al., 2014).