Although TB is also a risk factor for airflow obstruction in patients with HIV (Samperiz et al., 2014; Pefura-Yone et al., 2015; Gupte et al., 2017), in HIV positive patients with a low CD4 count (CD4 < 200/mm3) TB often presents with atypical CXR findings or even normal CXRs, while cavitation is 4-fold less common (Kwan and Ernst, 2011). This evidence concerns the gene CD4 and tuberculosis.