MAPK8 and cardiomyopathy: As mentioned earlier, Muchir and co-workers observed an activation of ERK, JNK and p38α cascades in hearts from LmnaH222P/H222P mice (Table 2), linking the activation of MAPK pathways due to LMNA mutations to cardiomyopathy (Muchir et al., 2007b, 2012b).