LMNA and Hutchinson-Gilford progeria syndrome: Lee JM et al. used an exon 11 antisense oligonucleotide (ASO E11-31) to shift the balance between lamin C and prelamin A splicing thus, increasing lamin C production in mouse and human fibroblasts, as well as reducing the expression of progerin in fibroblasts derived from patients with Hutchinson-Gilford progeria syndrome (HGPS) (Lee et al., 2016).