Emerin directly interacts and regulates the activity of HDAC3, regulating indirectly the expression and nuclear localization of myogenic differentiation genes, such as Myf5, MyoD and Pax7. It has been shown that EDMD-causing emerin mutations are not able to bind to HDAC3 (Demmerle et al., 2012, 2013). The gene discussed is EMD; the disease is Emery-Dreifuss muscular dystrophy.