LmnaH222P/H222P mice treated with SP600125, an inhibitor of JNK signaling, or with ARRY-371797, a p38α inhibitor, both showed a delay in the development of left ventricular dilatation and a reduction in the decrease of fractional shortening compared to placebo-treated mice (Wu et al., 2010; Muchir et al., 2012b). The gene discussed is MAPK8; the disease is Left ventricular dilatation.