As mentioned earlier, Muchir and co-workers observed an activation of ERK, JNK and p38α cascades in hearts from LmnaH222P/H222P mice (Table 2), linking the activation of MAPK pathways due to LMNA mutations to cardiomyopathy (Muchir et al., 2007b, 2012b). This evidence concerns the gene MAPK1 and cardiomyopathy.