SUN2 and Emery-Dreifuss muscular dystrophy: More recently, based on the common localization of these proteins, various genetic strategies, including candidate gene approaches, were undertaken in patients suffering from muscular dystrophies without mutations in EMD or LMNA. This has led to the identification of mutations or variants in genes encoding other nuclear envelope proteins such as FHL1B (Gueneau et al., 2009; Ziat et al., 2016), nesprin 1 and 2 (Zhang et al., 2007), SUN1/2 (Meinke et al., 2014), and LUMA (Liang et al., 2011) associated to a range of muscular dystrophies, some of them sharing clinical features of EDMD.