Ablation or knockdown of PLB has been demonstrated to suppress pro-arrhythmic Ca2+ waves generation in a model of CPVT (Bai et al., 2013), improve mortality rates in CSQ-transgenic mice [severe HF model, (Kaneko et al., 2016)] and importantly, improve contractile function in failing human cardiomyocytes (del Monte et al., 2002). The gene discussed is PLN; the disease is hydrops fetalis.