In a prediabetic model of metabolic syndrome, whereby dogs were chronically fed a high fat diet (HFD), phosphorylation of RyR2 at S2808 was significantly elevated and the channel’s ability to bind [3H] ryanodine significantly depressed in the ventricles compared to healthy controls, while no changes in RyR2 mRNA or protein expression were observed (Dinçer et al., 2006). This evidence concerns the gene RYR2 and metabolic syndrome.