RYR2 and type 2 diabetes mellitus: It has been demonstrated that blockade of CaMKII and inhibition of RyR2 phosphorylation in cardiac disease improves intracellular Ca2+ homeostasis and attenuates arrhythmogenesis (Ather et al., 2013; Tzimas et al., 2015; Uchinoumi et al., 2016), including in a rat model of type 2 diabetes (Sommese et al., 2016), but this is also not a universal finding (Chakraborty et al., 2014).