Abnormal Ca2+ release is the driving force for arrhythmia observed in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a condition characterized by pathogenic mutations in RyR2 (Priori et al., 2002; Priori and Chen, 2011), as well as in associated accessory proteins including CSQ (Terentyev et al., 2006; Nyegaard et al., 2012; Roux-Buisson et al., 2012). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.