However, if NCX1 is already diminished as shown in many models of diabetes (Makino et al., 1987; Pierce et al., 1990; Golfman et al., 1998; Hattori et al., 2000) additional inhibition was proven to be detrimental leading to adverse accumulation of Ca2+ in cytosol and cell death (Bögeholz et al., 2017). Here, SLC8A1 is linked to diabetes mellitus.