However, ablation has not alleviated HF development in all models and a mutant form of PLB unable to inhibit SERCa has been linked to lethal dilated cardiomyopathy in humans (Haghighi et al., 2003; Song et al., 2003; Sipido and Vangheluwe, 2010; Zhang et al., 2010). This evidence concerns the gene PLN and hydrops fetalis.