In 2013, the International Genomics of Alzheimer’s Project consortium analyzed >74,000 individuals, identifying 21 risk loci for AD besides APOE, 11 of which were novel susceptibility factors (Lambert et al., 2013); however, while such studies identified factors contributing to general susceptibility to AD, associations with specific endophenotypes, such as disease progression or cognitive functions, are less clear. This evidence concerns the gene APOE and Alzheimer disease.