APOE and Cognitive impairment: Additionally, we previously reported an association between the presence of at least one APOE-ε4 allele at baseline and DR neuropsychological performance among Pr-aMCI, Pss-aMCI, Pr-naMCI, and Pss-naMCI groups (Espinosa et al., 2013); however, the presence of the ε4 allele was only associated with the learning memory function NE for the Pss-aMCI phenotype, that is, for those MCI subjects with memory impairment and comorbidities, such as anxiety, depression, or cerebrovascular disease, that could explain their cognitive deficits.