A previous study (Cervantes et al., 2011) showed that, among genetic variants in the APOE cluster region, TOMM40 SNPs (Roses, 2010; Roses et al., 2010) were associated with progression from the MCI stage to AD (rs59007384 and rs11556510), as well as with shorter time to progression from MCI status to AD (rs10119); however, these results could not be replicated in independent cohorts. This evidence concerns the gene APOE and Alzheimer disease.