Remarkably, a recent proteomic analysis identified dysfunction in cellular transport, energy, and protein metabolism in different brain regions of individuals with atypical frontotemporal lobar degeneration (FTLD) with fused in sarcoma inclusions (aFTLD-U) associated with AP2A2 (Martins-De-Souza et al., 2012). Here, AP2A2 is linked to frontotemporal dementia.