LHB and Menkes disease: Since LHb bursting involves both NMDARs and low-voltage-sensitive T-type calcium channels (T-VSCCs; Yang et al., 2018), possible developmental delays in NMDAR subunits/function (Roceri et al., 2002; Rodenas-Ruano et al., 2012) and/or T-VSCCs expression and function following MD could occur and contribute to the increase in LHb bursting activity following MD.