LRP6 and Alzheimer disease: Through genome-wide linkage analyses, a broad susceptibility locus for late-onset AD was identified on chromosome 12, which includes the region encoding LRP6 (Pericak-Vance et al., 1997; Rogaeva et al., 1998; Kehoe et al., 1999; Scott et al., 2000; Mayeux et al., 2002; Myers et al., 2002; D’Introno et al., 2006; Lee et al., 2008).