These misfolded proteins and aggregates, containing proteins, such as TDP-43, FUS, C9orf72, superoxide dismutase (SOD1) and many others, are well-established pathological hallmarks of ALS (Okamoto et al., 1991; Watanabe et al., 2001; Arai et al., 2006; Neumann et al., 2006; Mackenzie et al., 2007; Kwiatkowski et al., 2009; Vance et al., 2009; Al-Sarraj et al., 2011). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.