FGF21 and colitis: FGF-21, as a member of an atypical subfamily of FGFs, acts as a hormone to modulate metabolism of glucose and lipids and metabolic adaptation when released into systemic circulation from the liver, muscles and adipose tissue.29 Also, FGF-21 is involved in inflammation and immune homeostasis by prevention of age-related thymic degeneration30 and modulation of inflammatory mediators in the progression of colitis.31 Given the close link between CRC and inflammation and metabolism, it is rational to infer that FGF-21 might be also related to colorectal carcinogenesis.