FGF21 and colorectal carcinoma: Family history of CRC is so far the most frequently, or even the only, factor used for risk discrimination in CRC screening for defining starting age at screening, and such risk stratification might be greatly enhanced in the future by considering additional, potentially even stronger risk predictors, such as more comprehensive scores based on easy-to-collect risk factors,39 genetic risk scores40 or protein biomarkers like FGF-21.