In this study, we identified ME1 as a frequently amplified gene by analyzing CNVs in two large datasets from breast cancer tissues (MEBTABRIC and TCGA) and patient-derived breast cancer cell lines (CCLE), and found that cases with ME1 copy number amplification had much higher ME1 expression than ones with no amplification, supporting that ME1 copy number amplification positively correlates with ME1 overexpression in breast cancer. This evidence concerns the gene ME1 and breast cancer.