To analyze tau fragmentation in AD, we performed immunoblotting with C-terminal specific (in-house C-ter-1) and N-terminal specific (Tau13) tau antibodies on post-mortem fusiform gyrus lysate from 35 control (32 for C-terminal analysis), 46 AD Braak III/IV (43 for C-terminal analysis) and 46 AD Braak V/VI patients (see Methods and Table 1). Here, MAPT is linked to Alzheimer disease.