We tested for association between common (MAF ≥ 1%) variants in HDL-related genes (ABCA1, APOA1, APOA2, CETP, GALNT2, LCAT, LIPG, NPC1, PLTP, and SCARB1) and HDL-C levels in patients with sepsis in the Derivation Cohort. The gene discussed is APOA2; the disease is Sepsis.