In fact, all of the 10 known causative SLS genes (NPHP16,7, NPHP28, NPHP39, NPHP410, NPHP5/IQCB111, NPHP6/CEP29012,13, NPHP10/SDCCAG814, NPHP13/WRD1915,16, NPHP15/CEP16417 and TRAF3IP118), variants of which are known to cause SLS, have been shown to have a strong relationship to cilia11,14,25–28. This evidence concerns the gene CEP290 and Sjogren-Larsson syndrome.