RPS27L and breast cancer: In our effort to determine potential effect of RPS27L on the growth of two breast cancer cell lines, we found that siRNA-based RPS27L silencing significantly triggered autophagy, an evolutionarily conserved catabolic degradation process to clear damaged organelles and recycle nutrients for the maintenance of cellular homeostasis and the adaptation to various stresses21,22, which has been previously shown to play important roles in breast cancer23,24.