In summary, the results from the present study are consistent with the fact that Hcy is a strong independent risk factor of AD, as Hcy induces memory and behavioral deficits, oxidative stress, neuroinflammation, synaptic and neuronal impairments, tau hyperphosphorylation and Aβ pathology, which were rescued by the TG supplementation, especially at high dose. This evidence concerns the gene MAPT and Alzheimer disease.