PMEL and neoplasm: The published literature reported that the tumor cells are positive for calcitonin (100%, 11/11), HMB-45 (90.1%, 10/11), CgA (54.5%, 6/11), CEA (36.4%, 4/11), S-100 (36.4%, 4/11), and CK (36.4%, 4/11).