These findings demonstrated that TLR8 and TLR9 play important roles in infectious diseases, and also emphasized the role of the rs3764880 SNP in TLR8 and rs187084 and rs5743836 SNPs in TLR9. To date, the SNPs of TLR8 and TLR9 have been studied in association with susceptibility to TB, but such studies addressing host genetic susceptibility to TB was limited, whether an association implies susceptibility for developing active disease or just acquisition of MTB infection is unclear. Here, TLR8 is linked to tuberculosis.