Moreover, in our earlier study, we have found that combination of both probiotics and celecoxib do have anti-neoplastic efficacy in early stage of experimental colon cancer, primarily by inhibiting the initiation and progression of colon cancer mainly due to down-regulation of pro-carcinogenic markers (COX-2, NF-κB, β-catenin) expression [19]. This evidence concerns the gene NFKB1 and colonic neoplasm.