Since most effectors of K-Ras are kinase porteins that promote cell proliferation, growth and cell survival [14], the action of mutant K-Ras and PI3K genes might synergistically give the mutant cell more cancer-like features in our in vitro culture [10] showing the colony-formed cell division compared to the typical (i.e. monolayer-formed) cell growth of WT. The gene discussed is KRAS; the disease is cancer.