MAP3K5 and cancer: The ability of flavonoids to cause apoptosis in cancer cells via the Akt pathway may be paradoxically mediated by a rapid imbalance in the intracellular ROS homeostass or, more probably, by the complex relationship between ASK1 and NF-κB, where IKK has a major control on the ASK1-JNK axis, associating IKK with ROS and ER stress [106].