The widest activity of flavonoids on apoptosis in cancer cells via the major survival signaling pathways would raise the question about which relationship does exist between autophagy and apoptosis [138], although a fundamental link with the Akt signaling pathway has been recently highlighted [139] and some major components of the fission and fusion machinery in mitochondria, i.e., dynamin-related protein 1 (Drp1), mitofusin1/2 (Mfn1/2) and Optic Atrophy 1 (OPA1), were reported to be involved in the mitochondria-related modulation of autophagy, besides apoptosis and necroptosis [140]. Here, AKT1 is linked to cancer.