NFKB1 and cancer: The most common route through which flavonoids induce apoptosis in cancer cells, i.e., the PI3K/Akt pathway, is probably the major signaling mechanism leading to cell survival gene expression with different approaches, e.g., PI3K/Akt/Raf1/MEK/ERK [129,130], PI3K/Akt/mTOR [131], and PI3K/Akt/ERK1-2/NF-κB [132].