AKT1 and lung adenocarcinoma: Furthermore, baicalein, by acting on the PI3K/Akt/NF-κB, enhances the sensitivity to cisplatin of A549 lung adenocarcinoma cell line [102].Flavonoids, acting on cells via the PI3K/Akt pathway, should regulate cell survival and apoptosis at a post-mitochondrial level, i.e., downstream of the mitochondria cytochrome c release and before the activation of caspase 9 [103].