Luteolin induces a caspase-dependent apoptosis in human hepatocellular carcinoma by inhibiting the Akt phosphorylation [100], and the flavonol glucoside icanin (40 μM) induces apoptosis via a ROS-mediated damage on mitochondria membrane potential by suppressing the PI3K/Akt and STAT3 signaling pathways [101]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.