COL1A1 and chronic obstructive pulmonary disease: Researchers have documented associations between various genes and health conditions that may impact sports participation; hypertrophic cardiomyopathy (HCM), connective tissue disorders, long QT syndrome (LQTS), cardiac arrhythmias, and collagen, type I, alpha 1 (COL1A1) variants associated with tendon rupture can all have a genetic basis and can cause symptoms or injury during exertion.