Similarly, Figure 4 displays the KEGG pathway, which was significantly enriched in the HIF-1α responsive gene corresponding to the reduced enrichment peaks expressed in the LB benzene treatment group compared with the control group, including the Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Fc epsilon RI signaling pathway, Pyrimidine metabolis, T cell receptor signaling pathway, and Transcriptional misregulation in cancer. This evidence concerns the gene HIF1A and cancer.