IL-24 treatment is known to induce the expression of various members of the extrinsic apoptotic pathway, such as Fas cell surface receptor (Fas), Fas ligand (FasL), Fas-associated death domain (FADD) in human ovarian cancer cells, and death receptor 4 (DR4), in colorectal cancer cell lines [33,34]. This evidence concerns the gene FADD and ovarian carcinoma.