Biochemical dissection of AD brain tissue identified pathological hallmarks of amyloid-β (Aβ)-containing amyloid plaques, and neurofibrillary tangles (NFT) comprising hyperphosphorylated Tau in both familial and sporadic patients [15], although Tau mutations were identified in other forms of dementia, collectively termed tauopathy [16]. Here, MAPT is linked to Alzheimer disease.