PIK3CA and cancer: Karolina et al. reported the presence of the oncogenic mutation biomarkers phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), Kirsten rat sarcoma viral oncogene homologue (KRAS), v-Raf murine sarcoma viral oncogene homolog B (BRAF), and tumor suppressor p53 (TP53) in salivary exosomes of cancer patients [14].