IGF1 and neoplasm: As shown in Figure 4, the most significantly enriched pathways included ones that are known to be associated with tumor cell proliferation and migration, such as the TGF-β, IGF-1 and ERK5 signaling pathways [51,52,53,54,55], and pathways involved in energy generation: Glycolysis and pyridoxal 5′-phosphate (PLP) salvage pathways.