FOXO3 and fatty liver disease: Among CCGs, UR increased the mRNA expression of Sirt5, Prkag2 (AMPK), and Foxo3 involved in lipolysis and FA oxidation, and decreased Cyp8b1 mRNA expression involved in bile acid synthesis compared to that in mice in the HFD group, which in turn induced a significant increase in the hepatic TCA cycle and oxidative phosphorylation, which may contribute to the reduction of hepatic steatosis.