Two different types of FLT3 mutations have been detected in malignant cells from AML patients: internal tandem duplication (ITD) in the juxtamembrane domain, which accounts for approximately 23% of AML cases, and point mutations (typically at codons D835 and I836) in the intracellular tyrosine kinase domain (TKD) observed in 7% of patients (Figure 2A) [6,33,34]. Here, FLT3 is linked to acute myeloid leukemia.