Vadastuximab talirine (SGN-CD33A) is an engineered CD33-directed antibody conjugated to pyrrolobenzodiazepine dimers that showed activity and a tolerable safety profile alone or in combination with standard chemotherapy or hypomethylating agents (HMAs), in AML patients enrolled in phase I studies [11,12,13,14]. The gene discussed is CD33; the disease is acute myeloid leukemia.