HIFs also modulate ECM remodeling through increased expression of prolyl-4-hydroxylases (P4HA1 and P4HA2), procollagen-lysine,2-oxyglutarate 5-dioxygenases (PLOD1 and PLOD2), and lysyl oxidases (LOX, LOXL2, and LOXL4), which are required for cancer cell invasion [5]. This evidence concerns the gene LOX and cancer.