Fluegen et al. showed that hypoxic microenvironments upregulate key dormancy genes, such as NR2F1, DEC2, and p27, in head and neck and breast cancer cells in mice and humans, which was accompanied by the overexpression of HIF-1 and glucose transporter 1 (GLUT1) [23]. The gene discussed is HIF1A; the disease is breast carcinoma.