LDHA and breast cancer: We observed that the LDH-A mRNA expression and the LDH intracellular activity were significantly increased in HT29-dx cells compared to HT29 cells, in accordance with Zhou et al., who showed an association between an increased expression and the activity of LDH-A in paclitaxel-resistant breast cancer cells, underscoring that siRNA knockdown of LDH-A reverses taxol sensitivity in resistant cells [25].