Subtype-3 muscarinic acetylcholine receptors (M3R) KO mice: Tsuboi et al. have reported that retinoic-acid-receptor-related orphan nuclear receptor gamma (ROR-γ) T antagonists suppress SS-like dacryoadenitis through the suppression of IL-17 and IFN-γ production by M3R-specific T cells, suggesting that Th1 cells interact with Th17 cells and collaborate with each other in the development of this disease [29]. This evidence concerns the gene IL17A and synovial sarcoma.