Desiccating stress dry eye model: A lymphocyte function-associated antigen-1 (LFA-1) antagonist, named “lifitegrast,” and an anti-intercellular adhesion molecule-1 antagonist have been shown to suppress IFN-γ family genes and improve the conditions of keratoconjunctiva sicca (KCS), including the corneal epithelial barrier dysfunction and goblet cell density/area of ocular surface but not lacrimal gland in a mouse desiccating stress dry eye model that develops KCS similar to SS [27]. The gene discussed is ICAM1; the disease is Keratoconjunctivitis sicca.