Pathways and molecules that are genetically associated with SS, including IRF-5 and the IFN signaling pathway, the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interferon regulatory factor 5 (IRF 5) pathway, the lymphocyte signaling pathway, and antigen presentation machinery [23]. The gene discussed is IRF5; the disease is synovial sarcoma.