RAG1 and sialadenitis: CD4+ M3R-reactive T cells produce IFN-γ and IL-17 in response to the N-terminal 1 and 1st extracellular loop peptides of M3R, and recombination-activating genes 1 (Rag1) KO mice that received N1- and/or first peptide-immunized splenocytes developed sialadenitis [30].