SIRT1 and heart disorder: Nevertheless, FOXO1 is a strong transcription factor activating many genes, these being: FASLG, IGFBP1, SOD2, PPARGC1A, ADIPOQ, APOC3, OSTN, BCL2L11, CCND2, and CDKN1B. The protein–protein interaction study also showed key interacting partners like GATA4, NKX2-5, SIRT1, CITED2, NFATc1 and TBX5, which are actively implicated in heart disorders and thus partly responsible for PS.