Other important genes such as Col4A1, EFNB2, EDNRB, FLT1, FOXO1, GAS6, HMGB1, STARD13, TRPC4, TUBA3C, ZIC2 are specifically associated with cardiovascular disorders, atrial and ventricular septal defects—the key disorders of PS (Table 1). Here, FLT1 is linked to cardiovascular disorder.