Molecular pathway and gene ontology analysis of chromosome 13 revealed the presence of important genes like FOXO1, Col4A1, HMGBB1, FLT1, EFNB2, EDNRB, GAS6, TNFSF1, STARD13, TRPC4, TUBA3C, TUBA3D. These genes are linked with cardiovascular disorders, atrial and ventricular septal defects commonly reported in PS [18,19,20,21,22,23,24,25,26,27,28,29,30,31]. Here, EDNRB is linked to cardiovascular disorder.