Other important genes such as Col4A1, EFNB2, EDNRB, FLT1, FOXO1, GAS6, HMGB1, STARD13, TRPC4, TUBA3C, ZIC2 are specifically associated with cardiovascular disorders, atrial and ventricular septal defects—the key disorders of PS (Table 1). Here, HMGB1 is linked to ventricular septal defect.