In surgical brain specimens from blunt traumatic patients, Suzuki et al. [32] demonstrated that vascular endothelial growth factors (VEGF), AQP1, and AQP4 were co-expressed in astrocytes located in the edematous tissue, confirming that astrocytes expressing AQPs and VEGF play a regulatory role in the water in- and out-flow in the injured tissue—a critical factor in the formation and resolution of brain edema. Here, VEGFA is linked to brain edema.