IGHE and allergic respiratory disease: This is not surprising, given that in respiratory allergy, the interpretation of SPTs and blood tests that measure specific serum IgE to whole allergen extracts traditionally relies on arbitrary cutoffs (e.g., SPTs > 3 mm, sIgE > 0.35 kUA/L), which have a relatively poor ability to distinguish between benign sensitisations and clinically relevant (‘pathologic’) sensitisation [1, 2].