Our results open new possible intervention strategies for the treatment of progeria and, in view of shear stress insensitivity occurring during normal endothelial aging (20, 23, 67) and of progerin accumulation in arteries of aged individuals (4), our study will also help to elucidate molecular processes of CVD in normal aging and find ways to unwrinkle the aged arteries. Here, LMNA is linked to progeroid syndrome.