Conversely, exogenous administration of FGF2 induced cytostatic or cytotoxic effects in breast cancer (Wang et al., 1998), Ewing's sarcoma family tumor (Williamson et al., 2004), and medulloblastoma (Fogarty et al., 2007) cell models among others. This evidence concerns the gene FGF2 and Ewing sarcoma/peripheral primitive neuroectodermal tumor.