Using intravital microscopy, we recently showed that Notch1‐driven T‐cell acute lymphoblastic leukemia (T‐ALL) cells (and particularly, chemoresistant clones) are highly motile with behavior that is seemingly independent from specific microenvironments.5 The role of cell motility and how this is directed by leukemia‐microenvironment interactions in AML pathogenesis has not yet been investigated.6 The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.